However, they also noted that the PASE “is strongly correlated with objective measures of physical activity.” 008) physical activity correlated with decreased APOE e 4-related cognitive decline.Īccording to the researchers, the subjective, self-reported measure of physical activity they used correlated with the risk for introducing recall bias. In post hoc subgroup analyses, both high intensity (estimate, 0.018 95% CI, 0.006-0.029 t = 2.91 P =. The researchers observed no significant association physical activity and longitudinal cognitive performance, but the interaction between physical activity, APOE e 4 and time was significant Kim and colleagues found higher physical activity linked to slower APOE e 4-related cognitive decline (estimate, 0.007 95% CI 0.003 to 0.011 t = 3.22 P =. The researchers evaluated physical activity using the Physical Activity Scale of the Elderly (PASE), a self-reported questionnaire that tracks the frequency, intensity and duration of activities in the previous week, and cognitive function using the Montreal Cognitive Assessment (MoCA).Ĭarriers of the APOE e4 allele tended to be younger (mean age, 60.9 years) than noncarriers (mean age, 64.1 years). They looked at 173 patients with PD (age, 63.3☑0 years 27% APOE e 4 carriers) and implemented a baseline of at least 2 years follow up. Kim and colleagues analyzed data from the Parkinson’s Progression Markers Initiative (PPMI) cohort, an international, multicenter cohort study developed to determine progression biomarkers in PD. However, no studies have yet reported on this interaction in. “These observations led us to hypothesize that physical activity also plays a role in modulating the association between APOE e 4 and cognition in PD. “Previous data indicate that physical activity modifies the APOE e 4 effect on the development and progression of AD,” Ryul Kim, MD, of the department of neurology at Inha University Hospital in South Korea, and colleagues wrote. The allele is recognized as “a major genetic risk factor” for Alzheimer’s disease and new data has shown it plays a role in cognitive impairment among patients with Parkinson’s disease, according to the researchers. Patients with Parkinson’s disease who increased their physical activity saw positive modification of the APOE e4 allele’s impact on early cognitive decline, according to findings from a multicenter cohort study published in Neurology. If you continue to have this issue please contact to Healio doi:10.1007/s1168-3.We were unable to process your request. The Alzheimer's Disease Assessment Scale-Cognitive-Plus (ADAS-Cog-Plus): an expansion of the ADAS-Cog to improve responsiveness in MCI. Skinner J, Carvalho JO, Potter GG, et al. Psychometric comparison of standard and computerized administration of the Alzheimer’s Disease Assessment Scale: Cognitive Subscale (ADASCog). O'halloran JP, Kemp AS, Salmon DP, Tariot PN, Schneider LS. The Alzheimer's Disease Assessment Scale-Cognitive subscale: normative data for older adult controls. Graham DP, Cully JA, Snow AL, Massman P, Doody R. Administration and scoring variance on the ADAS-Cog. How well do the ADAS-cog and its subscales measure cognitive dysfunction in Alzheimer's disease?. doi:10.1186/s1319-0īenge JF, Balsis S, Geraci L, Massman PJ, Doody RS. New scoring methodology improves the sensitivity of the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) in clinical trials. Verma N, Beretvas SN, Pascual B, Masdeu JC, Markey MK. Alzheimer's Disease Assessment Scale-Cognitive subscale variants in mild cognitive impairment and mild Alzheimer's disease: change over time and the effect of enrichment strategies. Podhorna J, Krahnke T, Shear M, Harrison JE. ADAS-Cog Administration and Scoring Manual. Journal of Neurology, Neurosurgery & Psychiatry 2010 81:1363-1368.įood and Drug Association. The ADAS-cog in Alzheimer's disease clinical trials: psychometric evaluation of the sum and its parts. The Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog): modifications and responsiveness in pre-dementia populations. Kueper JK, Speechley M, Montero-odasso M.
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